Protein Name interleukin 2 receptor, alpha chain
Organism Mus musculus
Gene ID 16184
Gene Symbol

Il2ra

UniProt P01590 (IL2RA_MOUSE), Q544I2 (Q544I2_MOUSE)
Relationships Total Number of functionally related compound(s) : 356
Total Number of Articles : 492
Description

interleukin 2 receptor, alpha chain

Gene Summary

Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow and yolk sac. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • interleukin-2 receptor subunit alpha
  • IL-2 receptor subunit alpha
  • IL-2-RA
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Properties