Protein Name isocitrate dehydrogenase 2 (NADP+), mitochondrial
Organism Mus musculus
Gene ID 269951
Gene Symbol

Idh2

UniProt P54071 (IDHP_MOUSE)
Relationships Total Number of functionally related compound(s) : 60
Total Number of Articles : 71
Description

isocitrate dehydrogenase 2 (NADP+), mitochondrial

Gene Summary

Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP+ biosynthetic process; carboxylic acid metabolic process; and negative regulation of matrix metallopeptidase secretion. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bone remodeling disease. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • isocitrate dehydrogenase [NADP], mitochondrial
  • ICD-M
  • IDH
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Properties