Protein Name angiotensin converting enzyme 2
Organism Mus musculus
Gene ID 70008
Gene Symbol

Ace2

UniProt Q8R0I0 (ACE2_MOUSE), Q3URC9 (Q3URC9_MOUSE)
Relationships Total Number of functionally related compound(s) : 161
Total Number of Articles : 215
Description

angiotensin converting enzyme 2

Gene Summary

Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • angiotensin-converting enzyme 2
  • ACE-related carboxypeptidase
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
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Properties