| Protein Name | Toll |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 43222 |
| Gene Symbol | Tl |
| UniProt | P08953 (TOLL_DROME), T2GGK5 (T2GGK5_DROME), A0A0B4KHY4 (A0A0B4KHY4_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
46
Total Number of Articles : 57 |
Description |
Toll |
| Gene Summary |
Enables several functions, including TIR domain binding activity; cytokine receptor activity; and virion binding activity. Involved in several processes, including Toll signaling pathway; nervous system development; and positive regulation of macromolecule biosynthetic process. Located in cleavage furrow; early endosome; and external side of plasma membrane. Is expressed in several structures, including ISN innervated muscle cell of A1-7; adult head; embryonic dorsal vessel; embryonic/larval aorta; and embryonic/larval heart. Used to study collagen disease; glucose metabolism disease; and primary immunodeficiency disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); dermatitis (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including TLR1 (toll like receptor 1); TLR10 (toll like receptor 10); and TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |