| Protein Name | platelet derived growth factor receptor, beta polypeptide |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18596 |
| Gene Symbol | Pdgfrb |
| UniProt | P05622 (PGFRB_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
179
Total Number of Articles : 261 |
Description |
platelet derived growth factor receptor, beta polypeptide |
| Gene Summary |
Enables platelet-derived growth factor receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study several diseases, including autism spectrum disorder; basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm; and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Jul 2025] |
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