| Protein Name | plasma-membrane associated cation-binding protein 1 |
|---|---|
| Organism | Arabidopsis thaliana |
| Gene ID | 827773 |
| Gene Symbol | PCAP1 |
| UniProt | Q96262 (PCAP1_ARATH), F4JUT9 (F4JUT9_ARATH), F4JUT8 (F4JUT8_ARATH) |
| Relationships |
Total Number of functionally related compound(s) :
29
Total Number of Articles : 12 |
Description |
plasma-membrane associated cation-binding protein 1 |
| Gene Summary |
Encodes a Ca2+ and Cu2+ binding protein. N-terminal myristylation on glycine 2 appears to enable it to associate tightly with the plasma membrane. Recombinant PCaP1 interacts strongly with phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and PtdIns (3,4,5)P3, and weakly with PtdIns(3,5)P2 and PtdIns(4,5). It also interacts with calmodulin (CaM) in a calcium-dependent manner. CaM does not interfere with PCaP1 membrane localization but does weaken interactions between it and the PtdInsPs. PCaP1 has an apparent Kd of 10 uM for Cu2+ and can bind six ions per protein. Transcript levels for PCaP1 first fall and then rise following exposure to CuCl2. Mannitol, sorbitol, and the flg22 oligopeptide also increase expression levels. |
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