CPRiL

PRMT1

protein arginine methyltransferase 1

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

• protein arginine N-methyltransferase 1
• HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
• heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
highly conserved protein 1
histone-arginine N-methyltransferase PRMT1
interferon receptor 1-bound protein 4
ANM1
HCP1
HRMT1L2
IR1B4