| Protein Name | phosphodiesterase 11A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 50940 |
| Gene Symbol | PDE11A |
| UniProt | Q9HCR9 (PDE11_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
16
Total Number of Articles : 35 |
Description |
phosphodiesterase 11A |
| Gene Summary |
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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