CPRiL

PTPN22

protein tyrosine phosphatase non-receptor type 22

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

• tyrosine-protein phosphatase non-receptor type 22
• PEST-domain phosphatase
• hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
lymphoid-specific protein tyrosine phosphatase
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
protein tyrosine phosphatase, non-receptor type 8
LYP
LYP1
LYP2
PEP
PTPN22.5
PTPN22.6
PTPN8