Protein Name phospholipase C delta 1
Organism Homo sapiens
Gene ID 5333
Gene Symbol

PLCD1

UniProt P51178 (PLCD1_HUMAN), A0A384MR47 (A0A384MR47_HUMAN), A8K8F9 (A8K8F9_HUMAN)
Relationships Total Number of functionally related compound(s) : 94
Total Number of Articles : 87
Description

phospholipase C delta 1

Gene Summary

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

synonyms
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
  • PLC-delta-1
  • Phospholipase C I 1
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Properties