| Protein Name | leucine-rich repeat kinase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 66725 |
| Gene Symbol | Lrrk2 |
| UniProt | Q5S006 (LRRK2_MOUSE), Q9CQG8 (Q9CQG8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
114
Total Number of Articles : 130 |
Description |
leucine-rich repeat kinase 2 |
| Gene Summary |
Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; protein import into nucleus; and protein phosphorylation. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Jun 2025] |
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