| Protein Name | glutamate decarboxylase 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24380 |
| Gene Symbol | Gad2 |
| UniProt | Q05683 (DCE2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
86
Total Number of Articles : 159 |
Description |
glutamate decarboxylase 2 |
| Gene Summary |
Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to brain-derived neurotrophic factor stimulus; and response to dexamethasone. Located in several cellular components, including inhibitory synapse; neuronal cell body; and synaptic vesicle membrane. Is active in GABA-ergic synapse and presynapse. Biomarker of autism spectrum disorder; bipolar disorder; epilepsy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |