Protein Name solute carrier family 6 member 3
Organism Rattus norvegicus
Gene ID 24898
Gene Symbol

Slc6a3

UniProt P23977 (SC6A3_RAT)
Relationships Total Number of functionally related compound(s) : 564
Total Number of Articles : 704
Description

solute carrier family 6 member 3

Gene Summary

Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • sodium-dependent dopamine transporter
  • DA transporter
  • DAT
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Properties