| Protein Name | bone morphogenetic protein 15 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9210 |
| Gene Symbol | BMP15 |
| UniProt | O95972 (BMP15_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
46
Total Number of Articles : 43 |
Description |
bone morphogenetic protein 15 |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016] |
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