| Protein Name | SUMO specific peptidase 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 26168 |
| Gene Symbol | SENP3 |
| UniProt | Q9H4L4 (SENP3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
40
Total Number of Articles : 38 |
Description |
SUMO specific peptidase 3 |
| Gene Summary |
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] |
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