| Protein Name | two pore segment channel 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 219931 |
| Gene Symbol | TPCN2 |
| UniProt | Q8NHX9 (TPC2_HUMAN), Q59G56 (Q59G56_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
44
Total Number of Articles : 59 |
Description |
two pore segment channel 2 |
| Gene Summary |
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009] |
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| Properties | |