CPRiL

GADD45A

growth arrest and DNA damage inducible alpha

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

• growth arrest and DNA damage-inducible protein GADD45 alpha
• DDIT-1
• DNA damage-inducible transcript 1 protein
DNA damage-inducible transcript-1
growth arrest and DNA-damage-inducible 45 alpha
DDIT1
GADD45