Protein Name growth arrest and DNA damage inducible alpha
Organism Homo sapiens
Gene ID 1647
Gene Symbol


UniProt P24522 (GA45A_HUMAN), A5JUZ3 (A5JUZ3_HUMAN)
Relationships Total Number of functionally related compound(s) : 277
Total Number of Articles : 319

growth arrest and DNA damage inducible alpha

Gene Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

  • growth arrest and DNA damage-inducible protein GADD45 alpha
  • DDIT-1
  • DNA damage-inducible transcript 1 protein
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