| Protein Name | leucine-rich repeat kinase 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 300160 |
| Gene Symbol | Lrrk2 |
| UniProt | F1LNJ1 (F1LNJ1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
43
Total Number of Articles : 33 |
Description |
leucine-rich repeat kinase 2 |
| Gene Summary |
Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to curcumin; nervous system development; and positive regulation of microglial cell activation. Located in axon; dendrite; and perikaryon. Is active in presynaptic cytosol. Used to study neurodegenerative disease and synucleinopathy. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
|
| Properties | |