| Protein Name | TNF receptor-associated factor 6 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 22034 |
| Gene Symbol | Traf6 |
| UniProt | P70196 (TRAF6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
184
Total Number of Articles : 204 |
Description |
TNF receptor-associated factor 6 |
| Gene Summary |
This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| synonyms |
|
| Properties | |