Protein Name hydroxysteroid 11-beta dehydrogenase 1
Organism Homo sapiens
Gene ID 3290
Gene Symbol


UniProt P28845 (DHI1_HUMAN), X5D2L1 (X5D2L1_HUMAN)
Relationships Total Number of functionally related compound(s) : 329
Total Number of Articles : 457

hydroxysteroid 11-beta dehydrogenase 1

Gene Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

  • 11-beta-hydroxysteroid dehydrogenase 1
  • 7-oxosteroid reductase
  • corticosteroid 11-beta-dehydrogenase isozyme 1
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