| Protein Name | dual oxidase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 53905 |
| Gene Symbol | DUOX1 |
| UniProt | Q9NRD9 (DUOX1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
67
Total Number of Articles : 112 |
Description |
dual oxidase 1 |
| Gene Summary |
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012] |
| synonyms |
|
| Properties | |