CPRiL

TBX21

T-box transcription factor 21

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

• T-box transcription factor TBX21
• T-box 21
• T-box expressed in T cells
T-box protein 21
T-box transcription factor expressed in T cells
T-cell-specific T-box transcription factor T-bet
transcription factor TBLYM
IMD88
T-PET
T-bet
TBET
TBLYM