Protein Name transforming growth factor beta 3
Organism Homo sapiens
Gene ID 7043
Gene Symbol


UniProt P10600 (TGFB3_HUMAN), A5YM40 (A5YM40_HUMAN), B3KVH9 (B3KVH9_HUMAN)
Relationships Total Number of functionally related compound(s) : 217
Total Number of Articles : 242

transforming growth factor beta 3

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]

  • transforming growth factor beta-3 proprotein
  • prepro-transforming growth factor beta-3
  • ARVD
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