| Protein Name | histone deacetylase 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15183 |
| Gene Symbol | Hdac3 |
| UniProt | Q3UM33 (Q3UM33_MOUSE), Q9JM08 (Q9JM08_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
97
Total Number of Articles : 108 |
Description |
histone deacetylase 3 |
| Gene Summary |
Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; regulation of DNA-templated transcription; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Jul 2025] |
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