Protein Name NLR family pyrin domain containing 6
Organism Homo sapiens
Gene ID 171389
Gene Symbol

NLRP6

UniProt P59044 (NLRP6_HUMAN)
Relationships Total Number of functionally related compound(s) : 34
Total Number of Articles : 26
Description

NLR family pyrin domain containing 6

Gene Summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

synonyms
  • NACHT, LRR and PYD domains-containing protein 6
  • NACHT, leucine rich repeat and PYD containing 6
  • PYRIN-containing APAF1-like protein 5
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Properties