CPRiL

TRADD

TNFRSF1A associated via death domain

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

• tumor necrosis factor receptor type 1-associated DEATH domain protein
• TNFR1-associated death domain protein
• tumor necrosis factor receptor type 1 associated death domain protein
tumor necrosis factor receptor-1-associated protein
Hs.89862