| Protein Name | interleukin 27 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 246778 |
| Gene Symbol | IL27 |
| UniProt | Q8NEV9 (IL27A_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
125
Total Number of Articles : 125 |
Description |
interleukin 27 |
| Gene Summary |
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |