CPRiL

ELOC

elongin C

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

• elongin-C
• RNA polymerase II transcription factor SIII subunit C
• SIII p15
elongin 15 kDa subunit
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
transcription elongation factor B polypeptide 1
transcription elongation factor B subunit 1
SIII
TCEB1