Protein Name assembly factor for spindle microtubules
Organism Homo sapiens
Gene ID 259266
Gene Symbol

ASPM

UniProt Q8IZT6 (ASPM_HUMAN), B3KWI2 (B3KWI2_HUMAN)
Relationships Total Number of functionally related compound(s) : 151
Total Number of Articles : 103
Description

assembly factor for spindle microtubules

Gene Summary

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

synonyms
  • abnormal spindle-like microcephaly-associated protein
  • abnormal spindle microtubule assembly
  • asp (abnormal spindle) homolog, microcephaly associated
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Properties