Protein Name insulin receptor substrate 1
Organism Mus musculus
Gene ID 16367
Gene Symbol


UniProt P35569 (IRS1_MOUSE), Q543V3 (Q543V3_MOUSE)
Relationships Total Number of functionally related compound(s) : 315
Total Number of Articles : 655

insulin receptor substrate 1

Gene Summary

Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

  • insulin receptor substrate 1
  • G972R
  • IRS-1
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