Protein Name toll-like receptor 9
Organism Mus musculus
Gene ID 81897
Gene Symbol

Tlr9

UniProt Q9EQU3 (TLR9_MOUSE)
Relationships Total Number of functionally related compound(s) : 275
Total Number of Articles : 436
Description

toll-like receptor 9

Gene Summary

Predicted to enable interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of defense response; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in intestine and small intestine mucosa. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • toll-like receptor 9
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Properties