| Protein Name | toll-like receptor 9 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 81897 |
| Gene Symbol | Tlr9 |
| UniProt | Q9EQU3 (TLR9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
275
Total Number of Articles : 436 |
Description |
toll-like receptor 9 |
| Gene Summary |
Predicted to enable several functions, including protein homodimerization activity; siRNA binding activity; and unmethylated CpG binding activity. Involved in several processes, including positive regulation of intestinal epithelial cell development; positive regulation of macromolecule biosynthetic process; and regulation of defense response. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of macromolecule metabolic process. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in brain and intestine. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Jul 2025] |
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