| Protein Name | retinoid X receptor alpha |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20181 |
| Gene Symbol | Rxra |
| UniProt | P28700 (RXRA_MOUSE), A2AJP1 (A2AJP1_MOUSE), Q6LC96 (Q6LC96_MOUSE), Q3UMU4 (Q3UMU4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
152
Total Number of Articles : 176 |
Description |
retinoid X receptor alpha |
| Gene Summary |
Enables DNA binding activity; DNA-binding transcription factor activity; and transcription coactivator binding activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of thyroid hormone receptor signaling pathway; and retinoic acid receptor signaling pathway. Acts upstream of or within several processes, including cardiac muscle tissue development; regulation of branching involved in prostate gland morphogenesis; and regulation of gene expression. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study congenital heart disease; dilated cardiomyopathy; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Jul 2025] |
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