Protein Name retinoid X receptor alpha
Organism Mus musculus
Gene ID 20181
Gene Symbol

Rxra

UniProt P28700 (RXRA_MOUSE), A2AJP1 (A2AJP1_MOUSE), Q6LC96 (Q6LC96_MOUSE), Q3UMU4 (Q3UMU4_MOUSE)
Relationships Total Number of functionally related compound(s) : 152
Total Number of Articles : 176
Description

retinoid X receptor alpha

Gene Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; regulation of branching involved in prostate gland morphogenesis; and regulation of cellular macromolecule biosynthetic process. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study congenital heart disease; dilated cardiomyopathy; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • retinoic acid receptor RXR-alpha
  • RXR alpha 1
  • nuclear receptor subfamily 2 group B member 1
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Properties