CPRiL

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• mitogen-activated protein kinase kinase kinase kinase 4
• HPK/GCK-like kinase HGK
• MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Ste20 group protein kinase HGK
epididymis secretory protein Li 31
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
nck-interacting kinase
FLH21957
HEL-S-31
HGK
MEKKK4
NIK