| Protein Name | methyl CpG binding protein 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29386 |
| Gene Symbol | Mecp2 |
| UniProt | Q00566 (MECP2_RAT), A0A0G2JWK2 (A0A0G2JWK2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
72
Total Number of Articles : 60 |
Description |
methyl CpG binding protein 2 |
| Gene Summary |
Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including central nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of fetal alcohol spectrum disorder; hepatocellular carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Jun 2025] |
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