Protein Name arachidonate 15-lipoxygenase type B
Organism Homo sapiens
Gene ID 247
Gene Symbol

ALOX15B

UniProt O15296 (LX15B_HUMAN)
Relationships Total Number of functionally related compound(s) : 60
Total Number of Articles : 53
Description

arachidonate 15-lipoxygenase type B

Gene Summary

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

synonyms
  • polyunsaturated fatty acid lipoxygenase ALOX15B
  • 15-LOX-B
  • 15S-lipoxygenase
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Properties