| Protein Name | heat shock factor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15499 |
| Gene Symbol | Hsf1 |
| UniProt | P38532 (HSF1_MOUSE), A0A075F5C6 (A0A075F5C6_MOUSE), Q52L52 (Q52L52_MOUSE), A0A075F891 (A0A075F891_MOUSE), A0A075F882 (A0A075F882_MOUSE), A0A075F6C2 (A0A075F6C2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
126
Total Number of Articles : 130 |
Description |
heat shock factor 1 |
| Gene Summary |
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; negative regulation of tumor necrosis factor production; and response to lipopolysaccharide. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |