Protein Name lysine (K)-specific demethylase 6A
Organism Mus musculus
Gene ID 22289
Gene Symbol

Kdm6a

UniProt O70546 (KDM6A_MOUSE), Q3TPN3 (Q3TPN3_MOUSE), Q3TNW2 (Q3TNW2_MOUSE)
Relationships Total Number of functionally related compound(s) : 22
Total Number of Articles : 36
Description

lysine (K)-specific demethylase 6A

Gene Summary

Enables DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and respiratory system process. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • lysine-specific demethylase 6A
  • [histone H3]-trimethyl-L-lysine(27) demethylase 6A
  • histone demethylase UTX
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Properties