| Protein Name | enhancer of zeste 2 polycomb repressive complex 2 subunit |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14056 |
| Gene Symbol | Ezh2 |
| UniProt | Q61188 (EZH2_MOUSE), Q6AXH7 (Q6AXH7_MOUSE), Q571L5 (Q571L5_MOUSE), Q3TZH6 (Q3TZH6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
137
Total Number of Articles : 219 |
Description |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
| Gene Summary |
Enables several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in B cell differentiation; cell development; and regulation of circadian rhythm. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022] |
| synonyms |
|
| Properties | |