Protein Name FMS-like tyrosine kinase 4
Organism Mus musculus
Gene ID 14257
Gene Symbol

Flt4

UniProt P35917 (VGFR3_MOUSE), Q5SU94 (Q5SU94_MOUSE)
Relationships Total Number of functionally related compound(s) : 85
Total Number of Articles : 77
Description

FMS-like tyrosine kinase 4

Gene Summary

Enables vascular endothelial growth factor receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • vascular endothelial growth factor receptor 3
  • chylous ascites
  • receptor protein tyrosine kinase
Click to show/hide the synonyms
Properties