Protein Name periostin
Organism Homo sapiens
Gene ID 10631
Gene Symbol

POSTN

UniProt Q15063 (POSTN_HUMAN), A0A024RDS2 (A0A024RDS2_HUMAN), A0A024RDT5 (A0A024RDT5_HUMAN), B1ALD9 (B1ALD9_HUMAN)
Relationships Total Number of functionally related compound(s) : 186
Total Number of Articles : 205
Description

periostin

Gene Summary

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

synonyms
  • periostin
  • osteoblast specific factor 2 (fasciclin I-like)
  • periodontal ligament-specific periostin
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Properties