| Protein Name | toll like receptor 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7100 |
| Gene Symbol | TLR5 |
| UniProt | O60602 (TLR5_HUMAN), A0A2R8Y7Z4 (A0A2R8Y7Z4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
84
Total Number of Articles : 85 |
Description |
toll like receptor 5 |
| Gene Summary |
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] |
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