| Protein Name | forkhead box O3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 56484 |
| Gene Symbol | Foxo3 |
| UniProt | Q9WVH4 (FOXO3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
243
Total Number of Articles : 321 |
Description |
forkhead box O3 |
| Gene Summary |
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |