Protein Name Casitas B-lineage lymphoma b
Organism Mus musculus
Gene ID 208650
Gene Symbol

Cblb

UniProt Q3TTA7 (CBLB_MOUSE), B9EKI5 (B9EKI5_MOUSE)
Relationships Total Number of functionally related compound(s) : 33
Total Number of Articles : 35
Description

Casitas B-lineage lymphoma b

Gene Summary

Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; and regulation protein catabolic process at postsynapse. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • E3 ubiquitin-protein ligase CBL-B
  • RING-type E3 ubiquitin transferase CBL-B
  • SH3-binding protein CBL-B
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Properties