| Protein Name | FOXF1 adjacent non-coding developmental regulatory RNA |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 400550 |
| Gene Symbol | FENDRR |
| UniProt | - |
| Relationships |
Total Number of functionally related compound(s) :
10
Total Number of Articles : 12 |
Description |
FOXF1 adjacent non-coding developmental regulatory RNA |
| Gene Summary |
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] |
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