| Protein Name | SET domain containing 2, histone lysine methyltransferase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 29072 |
| Gene Symbol | SETD2 |
| UniProt | Q9BYW2 (SETD2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
121
Total Number of Articles : 136 |
Description |
SET domain containing 2, histone lysine methyltransferase |
| Gene Summary |
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] |
| synonyms |
|
| Properties | |