| Protein Name | synaptojanin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 104015 |
| Gene Symbol | Synj1 |
| UniProt | D3Z656 (D3Z656_MOUSE), E9Q7S0 (E9Q7S0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
18
Total Number of Articles : 14 |
Description |
synaptojanin 1 |
| Gene Summary |
Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and synaptic vesicle uncoating. Acts upstream of or within several processes, including phosphatidylinositol dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Part of membrane coat. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
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| Properties | |