Protein Name | transforming growth factor beta receptor 1 |
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Organism | Homo sapiens |
Gene ID | 7046 |
Gene Symbol | TGFBR1 |
UniProt | P36897 (TGFR1_HUMAN), B4DY26 (B4DY26_HUMAN), Q5T7S2 (Q5T7S2_HUMAN), B4DXN7 (B4DXN7_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
324
Total Number of Articles : 437 |
Description |
transforming growth factor beta receptor 1 |
Gene Summary |
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
synonyms |
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Properties | |