Protein Name ATP-binding cassette, sub-family B member 4
Organism Mus musculus
Gene ID 18670
Gene Symbol

Abcb4

UniProt P21440 (MDR3_MOUSE)
Relationships Total Number of functionally related compound(s) : 122
Total Number of Articles : 175
Description

ATP-binding cassette, sub-family B member 4

Gene Summary

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • phosphatidylcholine translocator ABCB4
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4
  • P glycoprotein 2
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Properties