| Protein Name | regulator of G protein signaling 10 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6001 |
| Gene Symbol | RGS10 |
| UniProt | O43665 (RGS10_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
30
Total Number of Articles : 19 |
Description |
regulator of G protein signaling 10 |
| Gene Summary |
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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