Protein Name nfe2 like bZIP transcription factor 2a
Organism Danio rerio
Gene ID 360149
Gene Symbol

nfe2l2a

UniProt Q8JIM1 (Q8JIM1_DANRE)
Relationships Total Number of functionally related compound(s) : 121
Total Number of Articles : 103
Description

nfe2 like bZIP transcription factor 2a

Gene Summary

Enables protein heterodimerization activity and transcription cis-regulatory region binding activity. Contributes to DNA-binding transcription factor activity. Acts upstream of or within several processes, including cellular response to prostaglandin stimulus; larval feeding behavior; and positive regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including digestive system; female organism; heart; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • nuclear factor erythroid 2-related factor 2a
  • Nrf2a
  • nuclear factor (erythroid-derived 2)-like 2
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Properties